报告题目：Implantable, MEMS-based Opto-Electro Neural Interfaces for Optogenetics
报 告 人：Wen Li Assistant Professor
Abstract: Optogenetics holds great promise for fundamental neuroscience research and treatments of neural diseases and disorders. This technology combines techniques from optics and genetics to manipulate the activity of specific neurons with millisecond temporal precision and rapid reversibility. One critical challenge of optogenetics is sophisticated instruments for light delivery. This talk will describe examples of microfabricated hybrid opto-electro neural interfaces capable of optical stimulation and electrical recording of multilevel neural activities with relatively high spatial resolution. In one example, an Opto-μECoG array consists of epidural LEDs and transparent microelectrodes for stimulating and recording neural activity from superficial layers of the cortex. In another example, a 3-D optical neurostimulator combines LEDs and out-of-plane waveguides for optogenetic neuromodulation in deep cortical layers. In a third example, intracortical microelectrodes and wireless microelectronics are integrated with the 3-D optical stimulator to form a comprehensive system for deep brain neuromodulation. The efficacy of these devices has been demonstrated in optogenetic rat models.
Wen Li received her Ph.D. degree (2008) and M.S. degree (2004) in Electrical Engineering from California Institute of Technology. Before that, she studied in Tsinghua University and received her M.S. degree in Microelectronics (2003) and B.S. degree in Material Science and Engineering (2001). Her research interests include MEMS/NEMS technologies and systems, micro sensors and actuators, biomimetic devices and systems, microfluidic and lab-on-chip systems, and microsystem integration and packaging technologies.